The effects of different formulation variables on the transdermal absorption of donepezil were investigated. The permeation of donepezil from various pressure sensitive adhesive matrices was evaluated using flow-through diffusion cell system at 37°C. The penetration of donepezil from the matrices was found to be influenced by the nature of adhesives. 1:1 combination of acrylic rubber hybrid adhesives (Duro-Tak ® 87-503A and Duro-Tak ® 87-504A) provided good adhesion force and high flux of donepezil. Significant increase in flux was obtained using Brij ® 30, Brij ® 52, and their combination, as penetration enhancers. Manual assessment using thumb test revealed that patches containing combination of enhancers possessed good adhesive properties. The formulation containing combination of Brij ® 30 and Brij ® 52, each at the level of 5% v/w with 15% w/w drug load in 1:1 combination of Duro-Tak ® 87-503A and Duro-Tak ® 87-504A matrix was found to be the best. No significant alteration in morphology and assay values were observed during the physical and chemical stability tests conducted for the study period of 3 months.
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